Systemic delivery of
antisense oligoribonucleotide restores dystrophin expression in body-wide
skeletal muscles
Qi Long Lu,
Should Foot Surgery Be
Performed for Children With Duchenne Muscular Dystrophy?
J. Pediatr. 2005;25:95-7
Khristinn Kellie Leitch,, Naweed Raza, Doug Biggar, Derek Stephen, James G. Wright and Benjamin Alman - Canada
Abstract:
The authors conducted a retrospective study to determine the outcome of foot surgery in full-time wheelchair users with Duchenne muscular dystrophy. Medical records on all 88 teenaged boys with Duchenne muscular dystrophy treated at the authors’ institution were obtained and reviewed. Patients completed questions about shoe wear, pain, hypersensitivity, and cosmesis, and a foot examination was performed. There were no significant differences between patients who did and did not receive foot surgery with respect to shoe wear (p> . 0.05), pain (p> . 0.05), hypersensitivity (p> . 0.05), or cosmesis (p> . 0.05). Hindfoot motion was significantly better (p> . 0.05) but equinus contracture was significantly worse (p> . 0.05) in patients who had not had surgery.
Coagulation
system activated in Duchenne muscular dystrophy patients with cardiac
dysfunction
Toshio Saito, Yuko Yamamoto, Tsuyoshi Matsumura, Sonoko Nozaki,Harutoshi Fujimura, Susumu Shinno - Japan
Abstract
We investigated basic abnormalities of coagulation and fibrinolysis in Duchenne muscular dystrophy (DMD) patients with cardiac dysfunction. Forty seven patients with DMD, aged 13–37 years old, were enrolled. Based on left ventricular ejection fraction (LVEF) results determined by echocardiography, patients were divided into 3 groups: LVEF less than 30% (markedly depressed group), LVEF between 30 and 50% (slightly depressed), and LVEF greater than 50% (normal). We measured serum levels of total fibrin and fibrinogen degradation products (FDP), as well as plasma fibrinogen, thrombin–antithrombin complex (TAT), prothrombin fragment (F1C2), and D-dimer. The levels of TAT and F1C2 in the markedly depressed group were significantly elevated compared with the other groups, whereas FDP, fibrinogen, and D-dimer levels did not differ among the groups. We concluded that activated coagulation is associated with cardiac dysfunction in patients with DMD.